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Prescribers following NICE guideline NG87 or the AAP 2019 guideline should trial a first-line stimulant at an optimized dose for at least 4 weeks before concluding it has failed [5]

Pharmacovigilance activities during clinical trials include: Monitoring adverse events Reporting serious adverse events (SAEs) Signal detection and safety evaluation Risk assessment and mitigation Regulatory safety reporting Together, these activities help ensure that investigational medicinal products are evaluated safely and responsibly

doi:10.2337/db14-1577 11

Once patients get to mid to high doses of 8 to 12 mg, costs rise precipitously

Several potential pathways could link DHEA-S with frailty