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Long-term use of opioids can lead to constipation, dependence, nausea, indigestion, irregular heartbeats, and opioid-induced hormonal imbalance resulting in menstrual irregularities, impotence, enlarged breast in males, decreased energy, and libido
Neoplasia 13:864873 Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M (2014) Nrf2 enhances cholangiocyte expansion in Pten-deficient livers
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Genetic polymorphisms in oxidative stress-related genes are associated with clinical outcome in patients with advanced non-small cell lung cancer receiving tyrosine kinase inhibitors