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Joshua Goldenberg: You brought up a really interesting point with the biofilms, right

This expanding therapeutic landscape re-frames the standard 2.4 mg/week dose as a more modest regimen, further validating our use of a comparable human equivalent dose as a low dose in this preclinical model to specifically isolate and study the drugs weight loss-independent effects

Once you have taken the late dose, you can return to your normal schedule the following week

doi: 10.1016/j.jep.2021.114410 74 NotoAZahradkaPRyzNRYurkovaNXieXTaylorCG

The development of new models in which these pathways can be manipulated will aid this research and enable further investigation of promising therapeutic targets