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Differential role of angiotensin II receptor subtypes on endothelial supraoxide formation

More recently, it was shown that initial electron leakage and superoxide formation from complex III occur mainly towards the mitochondrial intermembrane space, leading to a mild oxidant stress in the cytosol and activation of a MAP kinase cascade with phosphorylation of c-Jun N-terminal kinase (hereinafter referred to as pJNK)

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10.3945/jn.113.185397 10 ChenJ