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Mechanisms of Weight Loss (The Brain and Gut) GLP-1 RAs promote weight loss through a gut-brain axis, acting on receptors in the CNS and gastrointestinal tract to regulate energy balance (Zheng et al., 2024)

doi: 10.1001/jama.281.21.2005

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For those considered overweight or having obesity, losing 5% or more of initial weight is linked to lessening cardiometabolic disease risk, with reductions in blood pressure, LDL cholesterol, triglycerides, and glycemia