(PubMed) Rader JI
J Agric Food Chem 60(23):56875692
Notes: Acute tolerance (a reduction in response for a given dose) develops rapidly (less than 1 hour), but not at the same rate for different physiologic effects (skin temperature, heart rate, subjective effects) Withdrawal symptoms such as cigarette craving can be reduced in most individuals by plasma nicotine levels lower than those from smoking Withdrawal from nicotine in addicted individuals can be characterized by craving, nervousness, restlessness, irritability, mood lability, anxiety, drowsiness, sleep disturbances, impaired concentration, increased appetite, minor somatic complaints (headache, myalgia, constipation, fatigue), and weight gain References: Belkoniene M et al (2019): Near fatal intoxication by nicotine and propylene glycol injection: a case report of an e-liquid poisoning
Dose: 1000 IU or less for women and between 2000-4000 IU for men could be recommended
N-acetylcysteine, or NAC for short, is a popular nutritional supplement for good reason