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Because the satiety-signaling mechanism is highly dose-dependent at the upper end of the titration schedule, Wegovy users should especially prioritize the abdomen as their default site to ensure they are getting the full benefit of their prescribed dose

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[81] confirmed that genetic deletion of NOS-2 in mice was without effect on allergen-induced airway hyper-responsiveness, but in contradiction to the Xiong study, genetic deletion of each of the three isoforms of NOS including NOS-2 had no effect on allergen-induced recruitment of eosinophils, granulocytes or mononuclear cells [81]