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Current gene therapy research aims to target, for example, upstream targets of the GSH system or molecules associated with it (such as Nrf2, GPX, SLC7A11), genes aberrantly expressed in myocardial injury, and noncoding RNAs regulating mRNA transcription [76, 202, 250,251,252,253]

American J Gastroenterology 116(5):878898

Biogenesis of Exos Unlike microvesicles, which are formed through direct outward budding from the plasma membrane, Exos are specifically created within multivesicular bodies (MVBs) through the endolysosomal pathway [50, 65]

PubMed Central , Drug Metabolism and Disposition , vol

In fact, patients with a glomerular filtration rate (GFR) below 60 mL/min /1.73 m present a 57% higher possibility of cardiovascular mortality