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These findings come predominantly from preclinical or small human studies and have not been confirmed by large-scale controlled investigations

The most important determinant of this compartmentalization is the polyglutamate tail

De Marchi F, Venkatesan S, Saraceno M, et al

H-RIF is influenced by various synergistic factors including sympathetic nervous system hyperactivity, proteinuria, inflammation, tubular hypertrophy, oxidative stress, and RAAS activation [31, 32]

Although a recent trial has shown to be beneficial when antiviral treatment is introduced early during the disease before hospitalization than later in the course of the disease, there is an urgent need for early therapies to reduce the risk of disease progression, prevent transmission, and be widely distributed to meet the worldwide demand (Gottlieb et al., 2022