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Orally administered semaglutide was administered for 10 consecutive days with dose escalation on the 5th day (5 days of 5 mg dosing followed by five days of 10 mg dosing) to avoid gastrointestinal side effects in both normal and renally impaired subjects

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Gastrointestinal Adverse Reactions In a pool of Study 1 and 2, gastrointestinal adverse reactions occurred more frequently among patients receiving ZEPBOUND (5 mg 56%, 10 mg 56%, 15 mg 56%) than placebo (30%)

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Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity