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PMID: 102 HenskeEPChengLHakimiAAChoueiriTKBraunDA

Opening of ATP-sensitive potassium channels inhibits l-valine induced GLP-1 secretion To investigate whether intracellular metabolism of l-valine leading to the production of ATP and closure of K ATP -channels, subsequently resulting in impaired K + efflux and cellular depolarization, was involved in the mechanisms of l-valine stimulated GLP-1 secretion, we infused the K ATP -channel opener diazoxide (250 M) while stimulating with l-valine (Fig

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Peptides show multimodal ligand binding through their interaction with various regions of the GLP-1R molecule