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First, rapid changes in blood glucose and insulin levels can affect skin hydration and nerve sensitivity

The effect of GLP-1R agonists on gut microbiota has been studied in clinical trials in T2D patients

It is worth mentioning that although only the genetic proxied GCGR/GLP-1R agonist showed causal effect on lowering level of BMI (Beta: -0.15, 95%CI: -0.23 to -0.07, P = 3.10 10 4 ), the target-specific MR analysis also indicated the causal effects of GLP-1R and GIPR agonist on BMI (GLP-1R agonist: Beta: -0.16, 95%CI: -0.27 to -0.06, P = 2.20 10 3

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