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A few months later, in January 1987 the group reported that the porcine peptide stimulated a small increase of insulin secretion from an isolated perfused pig pancreas and that they had observed a similar effect with a synthetic replica of the natural hormone
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however, in a meta-analysis of cohort studies comparing glargine to NPH, maternal and fetal outcomes were similar (142) and no adverse maternal or fetal effects have been described to date
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