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2015;161(Pt 2):41121

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A pharmacology that keeps amylin receptors tonically engaged, day and night, may reproduce amylins central appetite effects (which appear to tolerate sustained stimulation reasonably well) while behaving quite differently at the level of the stomach, where continuous braking could invite adaptive counter-regulation

Why Researchers Choose Cagrilintide Peptide Long-Acting Amylin Analogue: Engineered with prolonged half-life for sustained activity