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Pickart originally isolated GHK as the "growth factor" responsible for restoring proliferation to liver cells in older-donor plasma, and the copper-binding role was recognized shortly afterward as the molecular basis for many of the activities attributed to the peptide

A clinico-pathologic correlation is often required to ensure accurate diagnosis of systemic causes of diffuse pigmentation

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Higher glutathione levels mean better antioxidant defense, which can manifest as brighter, clearer, and more vibrant skin