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Phototherapy is frequently administered two to three times per week under clinical supervision and may be coupled with topical medications to augment efficacy

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Recently, we have reviewed in detail the immunosuppressive remodeling of the immune system in conjunction with aging [92]

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Deletion of SIRT1 in the anorexigenic POMC neurons attenuates leptin sensitivity and reduces energy expenditure, whereas over-expression of SIRT1 in POMC neurons sensitizes leptin signals and elevates energy expenditure [151, 152]