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& Raybould, H

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The standard protocol escalates gradually over 1620 weeks to minimise gastrointestinal side effects: Your physician may pause escalation at any dose if you are losing weight steadily and tolerating the medication well

In the Phase 1 multiple-ascending dose (MAD) study, VK2735 achieved up to 8.2% mean weight loss at day 28 for the highest dose (100 mg)

Moreover, chemical or genetic manipulation of GSH pool stimulated mitophagy but not general ATG