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On the other hand, different drug classes, namely fibroblast growth factor receptor21 (FGF21) analogues, that target directly hepatocytes, but also adipose tissue and the central nervous system, and possibly also hepatic stellate cells [37, 38, 39], have shown a potential to reverse earlystage cirrhosis [40]

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For individuals already predisposed to thin facial features or with age-related collagen decline, the transformation may be especially visible and distressing

A retrospective study evaluating patients with recurrent HE who achieved complete occlusion of portosystemic shunts compared to patients who did not undergo the procedure showed some benefits in embolization [81]