Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)
In an acidic environment, these nitrate-reducing bacteria take the nitrate found in our bodies and use it to produce nitric oxide, a very reactive chemical
Younossi ZM, Stepanova M, Al Shabeeb R, et al
Additionally, mast cell mediators can worsen edema, neuroinflammation, and neurotransmitter imbalance, intensifying the clinical picture
Some would consider a 25 mg naltrexone dose to be low dosage since its half of the naltrexone normal dosage of 50 mg