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Because of the short half-lives and absorption challenges of both compounds, the timing and division of doses are crucial for clinical success

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After 21 days, BW increased by 2.6% 0.71% in V rats and was reduced in the other cohorts by 8.7% 0.91% (CS), 5.6% 0.50% (PF) or 9.0% 0.42% (WM) (all P 3 C)

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