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Oral Pinealon is the route used in the small published human reports from the Khavinson group, including a 72-patient study in adults with consequences of traumatic brain injury and cerebrasthenia

Some compounded versions also include glycine or L-carnitine , which may support fat metabolism and muscle preservation during weight loss

Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels

Conclusion: Trial results and adverse event reporting systems report an infrequent incidence in patients using these medications, but this report aims to contribute to the literature describing this potential adverse event.