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However, as we mentioned, we really recommend the latter

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2015 NNMT consumes SAM as a methyl donor, competing with DNA and histone methyltransferases

This accumulation depletes the other types of folate required for purine and thymidylate synthesis, which are required for the synthesis of DNA

Contraindications and Precautions: AOD-9604 should be avoided or used only under close medical supervision in individuals with active malignancy or history of cancer, as the effects of the peptide on tumor growth have not been adequately studied