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Their primary role is to regulate glucose homeostasis, regulate gut motility, regulate appetite and regulate adiposity

Deficiency in vitamin B 12 is associated with neurological, cardiovascular, psychological, hematological, and gastrointestinal disorders, many of which require clinical intervention and hospitalization

The gastrointestinal system adapts to delayed gastric emptying over 12-16 weeks

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Notably, the insulinotropic effect of GLP-1 was lost in islets of NCC KO mice (Zhang et al., 2022b)