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ACE2 is widespread in different organs, including the respiratory and gastrointestinal tract, the brain, the kidneys, the heart, and vessels, and this is the reason why, although the main viral target still remains the respiratory epithelium, SARS-CoV-2 can potentially infect multiple tissues (123)

Assessment of the insulin response to a mixed meal by mathematical model analysis indicated that vildagliptin would improve -cell function in the short (28 days) and long term (52 weeks) [44,45]

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