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Kagawa H, Javali A, Khoei HH, Sommer TM, Sestini G, Novatchkova M, Scholte Op Reimer Y, Castel G, Bruneau A, Maenhoudt N, Lammers J, Loubersac S, Freour T, Vankelecom H, David L, Rivron N (2022) Nature 601:600605

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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 50 H 69 N 15 O 9 Weight: 1024.20 g/mol CAS: 121062-08-6 Structure: Cyclic heptapeptide with lactam bridge PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Soluble in water and acetic acid Selectivity: Non-selective MC1R/3R/4R/5R agonist Storage: Keep refrigerated 3646 F (28 C) Related products NAD+ $40.00 $125.00Price range: $40.00 through $125.00 MOTS-c $60.00 $190.00Price range: $60.00 through $190.00 CJC-1295 $60.00 $95.00Price range: $60.00 through $95.00 TB-500 $60.00 $90.00Price range: $60.00 through $90.00

Postmortem studies in AD patients reveal significant reductions in cerebral GLUT1 and GLUT3 expression (Szablewski 2021), accompanied by decreased activity of key glycolytic enzymes such as hexokinase and lactate dehydrogenase (Wu et al