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Safety Comparison# Key Differences Summary# Weight loss : Comparable (~20-21%), no head-to-head trial Mechanism : Amylin/GLP-1 (CagriSema) vs GIP/GLP-1 (tirzepatide) Molecules : Two-peptide combination vs single dual-agonist molecule Approval : Tirzepatide is FDA-approved

Middle, differences in the conformation of TM2 between the inactive and peptide-agonist-bound structures is also evident

Clinical and Translational Gastroenterology