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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)
Neuropharmacology 84:3145
cAMP formation initiates several downstream signaling pathways by activating downstream effector proteins such as protein kinase A (PKA) and exchange protein (Epac) activated by cAMP [31, 32]
This work was supported by the Lundbeck Foundation (fellowship R238-2016-2859), the BioInnovation Institute (grant number NNF20OC0063538) and the Novo Nordisk Foundation (grant numbers NNF17OC0026114 and NNF22OC0073778)
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