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Acetylcholine The cholinergic-adrenergic hypothesis of mood disorders, specifically the role of increased cholinergic activity in modulating depressed mood and sleep disturbance, has been supported by preclinical and human pharmacologic studies [212, 213]

Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors

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And thats where newer medications are effective, he added.