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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

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These include: Tingling, numbness, or a 'pins and needles' sensation in the hands and feet Difficulty with balance and coordination Muscle weakness Memory problems, difficulty concentrating, or 'brain fog' Mood changes, including low mood or irritability Important: New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change should be treated as urgent