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Systemic Toxicity: Excessive dosing may lead to systemic toxicity, characterized by central nervous system and cardiovascular manifestations

The results were unremarkable except for low vitamin D, high CRP, and elevated EBV IgG antibodies

A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions