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Clinical trials show tesamorelin can raise IGF-1 levels by over 180% while significantly decreasing abdominal fat deposits (Falutz et al., New England Journal of Medicine )

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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]