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The dose escalation design tested different starting doses (2 mg vs 4 mg) to evaluate tolerability

And we do that by looking not just at a drugs safety in those early trials but also by studying what its doing to the patients

However, increase fiber gradually over 23 weeks to avoid gastrointestinal side effects like bloating or constipation

Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR, Strotmeyer ES, Resnick HE, Carbone L, Beamer BA, Park SW, Lane NE, Harris TB, Cummings SR

Lack of effect of the glucagon-like peptide-1 receptor agonist liraglutide on psoriasis in glucose-tolerant patients: a randomized placebo-controlled trial