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Transient receptor potential melastatin 5 (TRPM5) KO (B6;129- Trpm 5tm1Csz/J) mice were obtained from Jackson Laboratory ( Heterozygous Trpm5 +/ mice were bred to obtain age- and sex-matched homozygous wild-type (WT) and homozygous Trpm5 / mice

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Methylcobalamin, a form of B12, is particularly essential for synthesizing neuronal lipids, regenerating axonal nerves, and exerting neuroprotective effects, potentially improving conditions such as Alzheimer's disease, Parkinsonism, and dementia, while also serving as an approved treatment for peripheral neuropathy

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