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In streptozotocin-induced diabetic mice, Ex-4 has been observed to regulate the cell cycle via the PKA/activating transcription factor 1 (ATF-1)/-catenin/cyclin D1 pathway, thereby enhancing proliferation of -cell [34]

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Under hyperglycemic conditions, exendin-4 partially restores cisplatin sensitivity in Ishikawa and HEC1B EC cells, with treatment performed at 10 nM for 48 h and accompanied by modulation of apoptosis-related proteins (183)

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