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2015;149(5):1163-1176.e2

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

Besides, elevated ROS also leads to the activation of astrocytes and microglia, along with the excessive generation of pro-inflammatory mediators (Solleiro-Villavicencio and Rivas-Arancibia 2018)

Consistent with the ion-centric model above, HIV-1 Tat can upregulate NLRP3, promote ASC oligomerization and caspase-1 activation, and augment IL-1 release by inhibiting miR-223, thereby contributing to microglial activation [101] (Fig

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