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Chemical Modulation Strategy Chemical modification, like PEGylation, enhances bioavailability of therapeutic peptides and proteins while preserving their pharmacological potency

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Wilson JM, Lin Y, Luo MJ, Considine G, Cox AL, Bowsman LM, et al

This enzyme achieves this promiscuity primarily through rapid transpersulfidation of C201 in a CstB-unique loop relative to a canonical PDO, followed by molecular shuttling of a covalently bound sulfonate group to a persulfidated C408, and thiosulfate release

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