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In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity

If collagen is the structural steel of the body, glutathione is the maintenance crew

By addressing oxidative stress and inflammation, the treatment aids in memory retention, improves mitochondrial function, and promotes overall mental clarity

Thus, RBC partitioning of drugs should be considered at least for these drugs with known RBC affinity

Arch Dermatol 2000