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1 mg of semaglutide is 40 units at 2.5 mg/mL, 50 units at 2 mg/mL, or 100 units (a full 1 mL syringe) at 1 mg/mL

In all in vitro and in vivo models used, tirzepatide was able to stimulate glucose-dependent insulin secretion via GIP and/or GLP-1 receptor activation

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While physicians have the legal authority to prescribe medications off-label when they believe it is in the patient's best interest, such use carries additional responsibilities for informed consent and monitoring

By combining these actions, tirzepatide achieves greater metabolic synergy than GLP-1 agonism alone