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Naltrexone-bupropion treatment was associated with clinically significant weight loss of close to 10%, reaching a nadir at 6 months and sustaining through 12 months (Table 2

So when LL-37 is used in Lyme circles, the goal is usually broader: pressure on mixed microbes, biofilm effects, and immune signaling that may help the body reset after repeated hits

The receptor itself couples to multiple G proteins (Gq/11, Gi/o, G12/13, and -arrestin), and different agonists can bias signaling toward different pathways (Overlapping binding site study, 2008)