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Animal studies also demonstrate the significant benefit of optimizing the levels of both GSH and VD-regulatory genes at the cellular/tissue level, in increasing 25(OH)-vitamin D levels and in reducing oxidative stress, TNF, and inflammation biomarkers in the circulation following co-supplementation with vitamin D and l-cysteine compared with vitamin D alone supplementation

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Additionally, ETV6 missense mutations can lead to a loss of its transcriptional regulation function due to impaired DNA binding and nuclear localization, thus promoting leukemogenesis [25, 26]