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Murman DL, Chen Q, Powell MC, Kuo SB, Bradley CJ, Colenda CC

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Here, an R g /R h value of 0.775 is characteristic of a compact, globular protein (sphere), whereas the larger values indicate a less compact or elongated structure, approaching 1.55 for a random-coil polymers (Tanford, 1966

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In both models, levels of thiomethyl metabolites were low (normalised area of S-CH3-APAP-S and SO-CH3-APAP-S represent less than 3 and 1% in PHH and HRG of all detected metabolites areas, respectively) compared to direct phase II conjugates (Fig