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The blockbuster new weight loss drugs, Wegovy and Ozempic, could become even more popular now that researchers have found that injections of semaglutide the drug in Wegovy and Ozempic sharply cut heart attacks, strokes and cardiac deaths in addition to helping people lose a significant percentage of weight

While the semaglutide CVOTs did not show an increased incidence of hospitalization for HF compared to placebo (101), in earlier smaller studies with liraglutide in patients with HF with reduced left ventricular ejection fraction, the GLP-1RA was associated with increased incidence of serious cardiac events (rhythm disorders, worsening of HF) (102, 103)

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Lipoic acid may also trigger antioxidant defense, enhance cellular glucose uptake, and modulate the activity of various cell-signaling molecules and transcription factors