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Combination therapy with gemcitabine further enhanced efficacy, with the mechanism involving increased lipogenic fibroblasts and reduced myofibroblasts to achieve dual-chamber targeting. Ent also attenuates the effects of TGF- and TGF- and antagonizes transcriptional activation (113)

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using total internal reflection fluorescence microscopy (TIRFM) combined with single particle tracking (SPT) would allow these phenomena to be observed at physiological agonist concentrations

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