Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g
These glucagon-based chimeric peptides were generated by amino acid substitutions to the glucagon sequence aimed at increasing potency at the GLP-1R and conferring balanced co-agonism at both receptors
Diabetes, Obesity & Metabolism, 16 ,
As a result, you can expect better results from the same dosage
Our goal in this series is not to persuade anyone to use medication, but to help readers understand when they may help, when they may harm, and when they are simply not the right tool