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Preclinical studies also indicate that tanycytes, specialized glial cells within the CNS, may facilitate the transportation of peripheral GLP-1RAs, such as semaglutide, into the CNS, bypassing the blood-brain barrier to access appetite-regulating hypothalamic regions such as the arcuate nucleus (60, 61)

The goal is to move your body in a way that feels manageable and sustainable

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This research shows how targeted, early-stage support can have an outsized impact, Kucenas said

As research on other administration methods develops, well update this information accordingly