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Make sure to let your health care provider know if you have any negative side effects as you increase the dose

Lebherz C, Kahles F, Piotrowski K et al (2016) Interleukin - 6 predicts inflammation - induced increase of glucagon - like peptide - 1 in humans in response to cardiac surgery with association to parameters of glucose metabolism

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A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

These include longer recovery with downtime, post-inflammatory hyperpigmentation (especially in darker skin types), infection, scarring, and prolonged erythema