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Considering that the SLC1A5 variant is an important regulator of the production of glutamine-derived -KG 16 , confirming whether epigenetic regulation by glutamine-derived -KG is affected by the SLC1A5 variant in cancer cells or stem cells is necessary (Fig

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Moreover, in patients with T2DM, islet amyloid polypeptide (IAPP or amylin), a peptide hormone and one of the main secretory products of pancreatic -cells, tends to deposit in the islets of Langerhans, form insoluble fibrils and impair secretory functions of -cells (93)

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