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When acting on the melanocortin 1 receptor (MC1R), melanotan stimulates melanin production and tyrosinase activity, leading to melanocyte proliferation and skin hyperpigmentation (Figure 3)

doi: 10.3803/EnM.2016.31.1.80 48 GibbonsCBlundellJTetens HoffSDahlKBauerRBaekdalT