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One study systematically demonstrated the feasibility of probiotics and prebiotics regulating OP via the brain-gut-bone axis, particularly emphasizing the central roles of SCFAs, intestinal barrier repair, and immunomodulation, with their efficacy corroborated by both animal experiments and human clinical data (263)

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These in-office procedures are typically followed up with relative rest and physical therapy

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Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model