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3.3 Insulin response In the prediabetes group, treatment with linagliptin did not alter fasting and postload serum insulin levels in prediabetes in both the low and high GLP-1 groups ( Table 3 , Figures 3AC )
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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and warnings for pancreatitis, gallbladder disease, acute kidney injury, and severe gastrointestinal disease
The Summary of Product Characteristics does not include sleep disturbances, insomnia, or related terms among the documented adverse reactions from clinical trials or post-marketing surveillance data
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